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2 Brain iron metabolism 2.1 Brain iron metabolism and its regulatory mechanisms Iron is an essential trace element required for maintaining normal function of the central nervous system (CNS)

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ADVERSE REACTIONS : Adverse reactions reported in 5% of patients treated with JANUVIA and more commonly than in patients treated with placebo are: upper respiratory tract infection, nasopharyngitis and headache

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The most pronounced differences were observed across gastrointestinal and metabolic events, including nausea (9,651 vs 38,030), vomiting (4,383 vs 17,062), pancreatitis (1,389 vs 6,655), and hypoglycaemia (773 vs 1,778), all substantially lower with combination therapy (Table 1)