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This NADP + -dependent dimerization/monomerization modulates FRET between the homologous fluorescent proteins (homoFRET) resulting in changes in steady-state fluorescence anisotropy that can then be used to assess the redox state of NADP + /NADPH

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However, these cells are highly sensitive to their environment, and elevated oxidative stress can physically trigger them to degranulate inappropriately

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