Takaya, K., Asou, T
Czeh, B., Simon, M., Schmelting, B., Hiemke, C
Compared with GPX1-3, GPX4 is also involved in the reduction of complex membrane-associated phospholipid hydroperoxides such as phosphatidylcholine hydroperoxide and cholesterol hydroperoxide, in addition to reacting with soluble, low molecular weight hydroperoxides such as t-butyl hydroperoxide and cumene hydroperoxide [68]
Sorafenib, an FDA-approved multi-target kinase inhibitor, is the first-line systemic therapy for advanced HCC
Glutathione is a potent antioxidant that plays an important role in protecting cells from oxidative damage
Glutathione-s-transferase (GST) protein is a widely used affinity tag for affinity purification