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PLoS One 10(9):0136618

February 2026: Zealand Pharma announced positive Phase II results for petrelintide alone that resulted in an 8.4% weight loss after 26 weeks of therapy

FACT: The FDA has approved semaglutide to treat specific life-threatening ailments like diabetes and obesity and was never intended to help people who have a healthy body mass index (BMI) and just want to drop a clothing size or two

Recent clinical data from semaglutide trials demonstrates average weight loss of 10-22% of body weight over 68 weeks depending on dose and baseline characteristics, making it highly effective as monotherapy for most patients

Consider switching from Qsymia to tirzepatide when weight loss plateaus after 6-12 months of treatment, or when patients experience limiting side effects like cognitive impairment or cardiovascular stimulation

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