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Adverse events observed at high exposure levels or in small, poorly controlled trials were sometimes taken as definitive evidence against a target
NRF2 knockdown was found to suppress the expression of fatty acid oxidation genes ACOX1, ACOX2, CPT1, and CPT2 [77], and NRF2 activation in the mouse lung induces the expression of fatty acid oxidation genes and lipases
In Grx1-roGFP2, the genetic fusion of a glutaredoxin to roGFP2 increases the effective local glutaredoxin concentration by 1000-fold [42], thereby allowing roGFP2 to equilibrate more rapidly with changes in E GSH
Melanotic schwannoma, a deceptive misnomer for a tumor with relative aggressive behavior: a series of 7 cranial and spinal cases
Nature 450 , 736740 (2007)
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