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NNMT is an enzyme that methylates nicotinamide (a form of vitamin B3), converting it to N1-methylnicotinamide and effectively removing it from the NAD+ salvage pathway

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Add to this the fact the procedure is often traumatic, I dont really like the results on most patients

The researchers did not observe a corresponding reduction in food intake during that short experiment

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The peptide proceeded through Phase IIb clinical trials for obesity, where it demonstrated favourable safety but failed to meet weight-loss endpoints at the doses tested