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Thus, the method is not an end-point analysis but it depends upon the K M value of GR

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Upon transferring wild-type and Gpx4-deficient T cells into the mouse model, while wild-type T cells proliferated normally post transplantation, Gpx4-deficient CD4+ and CD8+ T cells rapidly decayed within 7 days, undergoing ferroptosis, underscoring the innate role of Gpx4 in the proliferation and survival of CD4+ and CD8+ T cells [83]

doi: 10.1007/s00125-005-0126-y 199 LincoffAMBrown-FrandsenKColhounHMDeanfieldJEmersonSSEsbjergSet al