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Although the renoprotective effects of SGLT-2 inhibitors are maintained at these eGFRs, the glucose-lowering effects of SGLT-2 inhibitors are significantly impaired at low eGFRs

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Emerging indications (MASH, neuroprotection, seizure modulation, cravings, fertility/PCOS, pulmonary outcomes) expand the therapeutic horizon, while future pipelines (oral GLP-1s, triple agonists, amylin co-agonists) promise refined personalization and access

doi: 10.1111/bph.14083 129 Carvalho-SousaCEPereiraEPKinkerGSVerasMFerreiraZSBarbosa-NunesFPet al

Knowing that it is part of the insulin protein superfamily gives yet another clue to its importance