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GLP-1-based therapies, such as GLP-1 receptor agonists, glucose-dependent insulinotropic polypeptide (GIP) receptor agonists, and dipeptidyl peptidase 4 (DPP-4) inhibitors, improve glucose control through various mechanisms including increased insulin secretion, slower gastric emptying, and reduced postprandial glucagon and food intake

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For research protocol design purposes, this suggests that 48 weeks may be an insufficient observation window to capture the full weight loss potential of retatrutide at the 12mg dose

Foods to avoid on semaglutide and foods to avoid on tirzepatide overlap significantly, and they become even more important to avoid when dosing early

Primary prevention of cardiovascular and heart failure events with SGLT2 inhibitors, GLP-1 receptor agonists, and their combination in type 2 diabetes

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