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Sci Pharm (2015) 83:15975

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As a highly relevant translation, MPTP was first known to produce severe parkinsonism in humans (i.e., since 1982) [225]

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In support of this idea, when holoTC concentrations were subtracted from total vitamin B-12 concentrations, the remaining vitamin B-12, represented by the holohaptocorrin (holoHC) fraction of serum vitamin B-12, was unaffected by the concentration of plasma folate (Figure 8B)