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Exenatide (twice-daily) and lixisenatide are GLP-1 receptor agonists based on exendin-4 that overcome cleavage by DPP-4, however, their half remains short with ~ 24 h due to renal elimination

Indeed, the inhibition of complex 1 was observed in many cancer cells (Table 1) and usually leads to reduced mitochondrial OXPHOS and ATP depletion, ultimately resulting in AMPK-mediated activation of catabolic pathways and inhibition of anabolic processes through its regulation of mechanistic target of rapamycin complex 1 (mTORC1) (54)

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