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Louis, MO, USA) for 24 h, followed by transfer to PMA-free medium for another 24 h to obtain differentiated human macrophages

Peptide degradation occurs through several mechanisms including aggregation, oxidation, and deamidationprocesses accelerated by heat exposure

Comparisons during treatment were performed by one-way ANOVA with Tukey post hoc test

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Some individuals may eventually require a higher dose of 1.0 mg once weekly to achieve optimal weight loss outcomes