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But if you are overweight or have mild obesity without associated diseases, the risks may or may not outweigh the benefits

Diabetes Obes Metab (2014) 16(9):85060

So they're much, much, much larger molecule compared to the small peptides

We considered a subject to have a positive response to GLP-1 M if the median HbA1C within 12 months after the treatment decreased by more than 0.5% from the median HbA1C within 12 months before the treatment [13, 14]