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Increasing GSH and/or GSH-dependent antioxidant enzymes directly Many studies have concentrated on the direct effects of synthetic drugs on GSH and GSH-dependent antioxidant enzymes in damaged myocardium without further mechanistic investigations

TRIUMPH-3 (NCT05882045) will investigate change in bodyweight in people with overweight/obesity and cardiovascular disease, and TRIUMPH-4 (NCT05931367) will assess change in WOMAC score and bodyweight in individuals with overweight/obesity and knee OA

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They are being investigated as compounds that might address the specific biological bottlenecks that prevent normal healing

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