10.1107/s2052252524007784 102 ChiZ.ChenX.HoltzJ
Common B12 Deficiency Symptoms B12 deficiency symptoms can vary between individuals
The pivotal trial supporting its 2010 FDA approval enrolled 816 HIV-infected adults with clinically defined lipodystrophy, and Phase 3 data documented visceral fat reductions of roughly 15-18% over 26 weeks of treatment a result robust enough to clear FDA review for a defined medical indication
Hydroxocobalamin also binds nitric oxide, particularly in the absence of cyanide
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In research, this translates to a broad, body-wide potential for tissue repair, inflammation modulation, and angiogenesis (the formation of new blood vessels)