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Phosphorylation of the DSGIS motif in NRF2 mediated by glycogen synthase kinase-3 beta (GSK-3) promotes the binding of -TrCP to NRF2 which is therefore marked for ubiquitination and then degraded by the proteasome [145, 149,150,151]

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Table 4: Number and percentage of dogs with adverse reactions in the 6-month open-label clinical study for PROIN Chewable Tablets a Percent of dogs with systolic blood pressures of 160 mmHg on day -7 were 30.2% and on day 0 were 33.3%