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The cells are often distributed in a periadnexal arrangement

One of the RCTs found significant mean improvements in Clinical Global Impressions-Improvement (CGI-I) score and cellular methylation capacity, but not in the Aberrant Behaviour Checklist (ABC), Social Responsiveness Scale (SRS) or GSH metabolism, with those who had the lowest methionine status at baseline (suggesting impaired methylation capacity) significantly more likely to respond to supplementation

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Available from: Pontes FSC et al (2018) Melanotic neuroectodermal tumor of infancy of the jaw bones: update on the factors influencing survival and recurrence