In the Phase 3 REDEFINE-1 trial, adding cagrilintide to semaglutide pushed average weight loss from 14.9% to 20.4%
And since having too much B12 isnt harmful (the body simply excretes the excess), its easier and cheaper to just get a shot (B12 injectables cost $14 apiece if bought online or $20 to $70 at a spa or doctors office)
Here's what to run, when to run it, and how to stack it based on four distinct goals
Injectable administration likely achieves higher blood concentrations, though comparative human data does not exist
Testing is the best way to confirm a deficiency before supplementing
In a phase 1b trial, 20 weeks of cagrilintide 2.4 mg once weekly in combination with semaglutide 2.4 mg once weekly (cagrisema) resulted in up to 17.1% WL compared to 9.5% WL with semaglutide 2.4 mg plus placebo in people with obesity [88]