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SKU: 85956151330

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Description

The mitogenic activity of the IGF-1R is mediated through the Ras and AKT pathways and results in the upregulation of cyclin D1 and its binding partner CDK4, leading to the phosphorylation of retinoblastoma protein, release of E2F transcription factor, and expression of downstream target genes like cyclin E [23, 24]

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F., & Oyinloye, B

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Laake J-PS, Stahl D, Amiel SA, Petrak F, Sherwood RA, Pickup JC, et al

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Horticulturae 8:645

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