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If the cut-off for deficiency is set higher, you diagnose more people who have deficiency, but you also end up treating more people who dont have a deficiency

Some people may have no symptoms at all, even with low B12 levels

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Relative fold change in cell number of the indicated HEK-293T SLC25A39 knockout cells expressing vector or SLC25A39 cDNA transduced with the indicated sgRNAs

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