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2023 doi:10.1097/LVT.0000000000000298 25

[6] Berberine Hydrochloride : Berberine does increase GLP-1, but the effect is tiny and not clinically comparable to prescription GLP-1 drugs and some research suggests it may help with weight loss, but human evidence is limited

Ann Gastroenterol

Type 1 contains vildagliptin and saxagliptin, which bind only to the S1 and S2 subsites and form a covalent bond with the nitrile group of their cyanopyrrolidine moiety and Ser630 of DPP-4

Both pill and injection forms work through similar mechanisms to promote weight loss

Furthermore, GLP-1 augments mitochondrial efficacy, as manifested by the ameliorated oxidative metabolism of muscle tissue