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The 4mg dose is often where researchers consider microdosing because the side effect jump from 2mg is significant
Johnson B et al
Peptides 18 , 625632 (1997)
Davies M, Frch L, Jeppesen OK, et al
In the case of GLP-1s, this can mean semaglutide or tirzepatide made in a compounding pharmacy rather than dispensed as an FDA-approved brand-name product
Individuals should contact their GP or a relevant specialist before considering retatrutide if they have any of the following: A personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2 (MEN2): Rodent studies with GLP-1 receptor agonists have identified thyroid C-cell changes
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