Results can vary widely
Kennedy D, Samali A, Jger R (2015) Methods for studying ER stress and UPR markers in human cells
Restoration experiments then introduce exogenous glutathione or precursors and measure recovery of redox markers, enzyme activity, and viability parameters, establishing causal relationships between GSH levels and cellular outcomes
The evolutions in the field of drug discovery open the way to a new generation of senolytic therapies, such as immunological approaches (CAR-T cells, Antibody-Drug Conjugated or vaccines), which require preliminary steps of research to identify markers specifically expressed on senescent cells, demonstrating promising specific effects
Acetyl CoA acetyl coenzyme A ADP adenosine diphosphate ATP adenosine triphosphate BNIP3 Bcl-2 interacting protein 3 CaOx calcium oxalate CypD cyclophilin D ETC electron transport chain FADH 2 flavin adenine dinucleotide GSSG glutathione disulfide H 2 O 2 hydrogen peroxide mGSH mitochondrial glutathione MIM mitochondrial inner membrane MOM mitochondrial outer membrane mtDNA mitochondrial DNA NADH nicotine adenine dinucleotide O 2 superoxide ROS reactive oxygen species TCA tricarboxylic acid Abbreviations References 1 AbateM.FestaA.FalcoM.LombardiA.LuceA.GrimaldiA.et al
A quantitative overview of glucose dynamics in the gliovascular unit
