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Food and Drug Administration (FDA) just approved Zepbound (tirzepatide) for chronic weight management

The most-affected pathways include antioxidant defense, DNA repair, ubiquitin-proteasome activity, and TGF-beta signaling

Their action signals the cell to modulate its response, through the recruitment of endogenous coping mechanisms, among which are an increased synthesis of antioxidants and of electrophile quenchers, the transcription of the necessary gene products and the production of reducing cofactors such as NADH/NADPH and ascorbate

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doi:10.1186/s12944-018-0779-4

[DOI] [PubMed] [Google Scholar] 58.Hernandez-Perera O, Perez-Sala D, Navarro-Antolin J, Sanchez-Pascuala R, Hernandez G, et al