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Older performance horses often exhibit blunted GH pulse amplitude compared to younger animals, which has prompted veterinary researchers to ask whether exogenous GHS compounds could restore more youthful secretory patterns without disrupting other hormonal axes

Factors affecting efficacy include existing endothelial function, individual amino acid metabolism, comorbidities (diabetes, metabolic syndrome, prior cardiovascular events), and - critically - dose

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found that rifaximin did not affect the overall composition of intestinal microflora, but caused an increased concentration of Bifidobacterium, Atopobium and Faecalibacterium prausnitzii, accompanied by increased short-chain fatty acids [157]

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