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Weight loss plateaus are common after 3 to 6 months on any fixed dose, a phenomenon called metabolic adaptation

The most common switch happens between 10 mg/mL and 20 mg/mL when the dose reaches 12.5 mg or 15 mg

There are two serotypes of HSV, HSV-1 and HSV-2, with similar genome structure, about 50% homology of nucleic acid sequence and about 83% homology of protein coding region

The mitochondrial TCA cycle is disrupted due to transcriptional repression of SUCLG2 , impairing the conversion of -KG into succinate

These were originally investigated for diabetes, on the theory that GLP-1 increases insulin and thus decreases blood sugar

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