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instead, professional medical intervention in a controlled setting is essential

doi: 10.1038/bmt.2013.107 106 GergoudisSCDeFilippZzbekUSandhuKSEtraAMChoeHKet al

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GLP-1 receptor agonists enhance insulin secretion, suppress glucagon, delay gastric emptying, reduce appetite, and rarely cause hypoglycaemia, though nausea is common [249]

The leading explanation is amplification of a pain-signaling channel on skin sensory nerves (purinergic ATP/P2X signaling). Symptoms were usually mild and eased after dose reduction