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Note any episodes of rapid heartbeat, palpitations, or chest discomfort

Cytochrome P450 2E1 (CYP2E1) mRNA is not reduced by GHK-Cu (RT-qPCR: P=NS), indicating protection is downstream of NAPQI generation consistent with Nrf2-driven GSH replenishment and antioxidant enzyme upregulation rather than reduced toxic metabolite production

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This dual functionality establishes it as a complex yet promising target for cancer treatment (216)

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