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Certain ingredients may require dose adjustments or may not be suitable in severe renal dysfunction

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Strong CYP3A inhibitors (such as ketoconazole, itraconazole, and ritonavir) would be expected to increase orforglipron exposure, potentially necessitating dose adjustment

The choice between metformin and GLP-1s, or any other blood sugar lowering medication, should be made based on individual factors, including the patient's medical history, lifestyle, treatment goals, and potential side effects

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