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Critical role of the cAMP-PKA pathway in hyperglycemia-induced epigenetic activation of fibrogenic program in the kidney

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Examples include permanent vision loss, severe gastroparesis requiring feeding tubes, or kidney failure requiring dialysis

Petrie JR, Chaturvedi N, Ford I et al (2017) Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial

Chokshi RV, Hovis CE, Hollander T, et al