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Symptoms of deep vein thrombosis (DVT) typically affecting the legs include: Swelling in one leg (rarely both) Pain or tenderness, often starting in the calf Warmth in the affected area Red or discoloured skin Visible surface veins Symptoms of pulmonary embolism (PE) , a potentially life-threatening complication when a clot travels to the lungs, include: Sudden shortness of breath or difficulty breathing Sharp chest pain that may worsen with deep breathing or coughing Rapid heart rate or palpitations Coughing up blood Feeling lightheaded or fainting Unexplained anxiety or sense of impending doom Patients should seek immediate medical attention (call 999 or attend A&E) if they experience symptoms suggestive of pulmonary embolism

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MT-2s cyclic structure confers significantly enhanced resistance to enzymatic degradation, with an effective research half-life of approximately one to two hours, providing a substantially wider in vitro and pre-clinical experimental window than the endogenous compound