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A deficiency in B12 can lead to symptoms such as fatigue, weakness, memory problems, and neurological issues

The 177191 fragment was identified as the lipolytic active site, and a tyrosine residue was added at the N-terminus to enhance stability

(October 2017)

Common issues include gastrointestinal (GI) discomfort, such as nausea, vomiting, diarrhea, and constipation, especially in GLP-1 receptor agonists like semaglutide and liraglutide

No case series using dicobalt edetate or 4-dimethylaminophenol were identified, but successful use in single cases has been reported

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