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While the least common of all CHE subtypes, the risk of developing PCD-driven disease increases when there is an interruption of the stratum corneum, potentially relating to filaggrin or other gene mutations

However, several modern factors can deplete our natural stores: Environmental Stressors: Pollutants in the air and water can increase the demand for antioxidants

Glutathione Glutathione is a natural, powerful antioxidant system in your body

Glutathione is a vulnerable, unstable nutrient that will quickly oxidize (degrade) in supplement form

The immunomodulatory effects of PDGFR/ + CAFs have also been well-documented in several studies