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One possible explanation is that low serum vitamin B12 levels would trap folate as 5-methyltetrahydrofolate, prevent the generation of methionine from homocysteine, and therefore reduce protein synthesis and lean tissue deposition

When concentrations of this amino acid are too low, deficiency can develop

Increase Vitamin C Intake Vitamin C helps recycle glutathione

Thus suggesting a specificity for IGF-1R

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5 ways to support glutathione levels Adjusting lifestyle habits like sleep hygiene, nutrition, and getting regular exercise can significantly boost glutathione production in your body