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Thistle was used for centuries, and English herbalist Nicholas Culpeper suggested using it in the sixteenth century to cure a variety of conditions, such as jaundice and to help get rid of stones (Akhtar et al., 2023)

The increase in hypoglycemic therapies with a favorable cardiovascular profile has revolutionized the treatment of T2D and the main drawback is the high cost associated with newer therapies

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