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When you're losing weight quickly - whether through GLP-1 therapy, caloric restriction, or a combination - your body pulls energy and raw materials from whatever it can access most efficiently

And, in fact, Novo Nordisk produces another semaglutide medication specifically for weight loss called Wegovy

SECOND OPINION SERIES Why MTHFR Testing Fails Mental Health Patients and How Folate Worsens Anxiety or Depression Folate anxiety and depression are increasingly reported by patients who feel worse after starting folic acid, folinic acid or methylfolate

Am J Clin Nutr 51(5):759767

This was borne out of two issues

dysregulation increases the labile iron pool, which catalyzes the Fenton reaction to generate hydroxyl radicals that initiate lipid peroxidation (27)