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The results showed no significant dependence of the cellular uptake of nanoparticles on the oxygen concentration in the cells (Supplementary Fig

Liu Z, Liu M, Cao Z, et al

Alzheimer's disease microbiome is associated with dysregulation of the anti-inflammatory P-glycoprotein pathway

Notably, in these studies, the upregulation of GPx4 has been achieved by using exogenous agents (like NVP-AUY922, Bafilomycin A1, PD151746, GsMTx4, epigallocatechin-3-gallate, total flavonoids of Engelhardia roxburghiana leaves, Lycium barbarum polysaccharide-glycoprotein, perillaldehyde, melotonin, ferulic acid, and sphingosine-1-phosphate) which either inhibit the degradation of GPx4 or increase its transcription by activating the Nrf2 [67]

Fecal microbiota transplantation significantly improved respiratory failure of amyotrophic lateral sclerosis

Table 1