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The major pools of folate derivatives are found in the liver followed by the kidneys where they are distributed between the cytosol and the mitochondria

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doi: 10.1016/j.gene.2017.09.016 39 DubeyBJacksonMZeigler-JohnsonCDevarajanKFlores-ObandoREMcFarlane-AndersonNet al

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The Phase 3 REDEFINE program is ongoing