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For all compounds, molecular descriptors including molecular weight, logP, topological polar surface area (tPSA), hydrogen bond donors/acceptors, rotatable bonds, aromaticity indices, and charge-related parameters were computed using QikProp from Maestro Desmond (Schrdinger Release 2024-3: QikProp, 2025)

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Explants were exposed to 100 mM KCl to depolarise OB neurons (Supplementary Fig

This was only 0.8% less than users of brand-name versions in the same period, reinforcing its potential as a powerful tool for weight management

Improved health outcomes: These medications can also help improve blood sugar levels, lower blood pressure, and reduce the risk of heart disease for people with obesity or overweight conditions