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The site noted that tirzpatide offered an average of 22.5% body weight loss (whereas semaglutide offered an average of 15-16% body weight loss)

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GLP-1 receptor agonist drugs (e.g., semaglutide, liraglutide, tirzapeptide) work by mimicking natural GLP-1 but last much longer

Recommended starting dose: Discontinue other basal insulin and/or GLP-1 agonist before initiating Soliqua Patients naive to basal insulin or a GLP-1 agonist, currently on a GLP-1 agonist or less than 30 units of basal insulin daily: starting dose is 15 units once daily Patients currently on 30 to 60 units of basal insulin daily, with or without a GLP-1 agonist: starting dose is 30 units once daily Maintenance: titrate dose up or down by 2 - 4 units every week based on blood sugar goals Missed doses: resume dosing at the next scheduled dose

While concerns have been raised at the sheer cost of medicating obesity to the healthcare system the National Health Service (NHS) in the UK currently only covers Wegovy for a two-year period the coming wave of lower-cost generic alternatives could make this more viable

PMID 20727946