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The development of drugs targeting the CNS requires precise knowledge of their penetration into the brain 2 , and ideally, this information should be obtained as early as possible to avoid failure in late clinical development, when upward of $100 million is typically invested in a drug candidate

10.1152/ajplung.90369.2008

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42,43 A cross-sectional study in HIV patients treated with antiretroviral nucleoside analogs showed that in patients with axonal peripheral neuropathy ALC levels are significantly lower compared to the control groups