It can interfere with JAK signal transduction and STAT signaling pathway by inhibiting the activity of one or more JAKs, and simultaneously inhibit the production of multiple cytokines to reduce inflammation and inflammation-related pain (225, 226)
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For a minority, particularly those with pre-existing imbalances in serotonergic function, the shift could theoretically contribute to anxiety symptoms
doi: 10.1038/nrd.2017.16 148 NajjarS.PearlmanD
By activating the expression of SOD1, NRF2 helps maintain cellular redox balance and protects cells from oxidative injury [38]