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In comparison, the pancreatic islets isolated from the GLP-1R knock-out mice secreted 2 to 4-fold less insulin after incubation with GLP-1 WT, GLP-1 QMP, or Exendin-4, similar amounts to that measured for unfused WT albumin (Fig

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Overall, dapagliflozin is unlikely to affect the pharmacokinetics of concurrently administered medications that are P-gp, OCT2, OAT1, or OAT3 substrates