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The authors also noted that further optimisation was needed, including work relating to high clearance in mice and off-target activity against monoamine oxidase A

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In Phase 3 trials

Reconstitution note: Tesamorelin is strongly cationic and prone to injection-site welts, so reconstitute with 0.9% NaCl bacteriostatic water rather than plain BAC water the sodium and chloride ions screen the peptides charge and shrink the welt

Protocol adjustment over years should account for changing skin needs

Their diet may not be as good for absorbing B12