EMPA-REG Kidney Visual Abstract While empagliflozin was the first out with a CVOT, canagliflozin was the first to complete a kidney-focused flozin trial, CREDENCE, which convincingly answered any doubts from the earlier trials
Ozempic, Wegovy and Mounjaro are all administered on a weekly basis through a subcutaneous injection, with the outlier being Mounjaro due to the significantly higher starting dosage (2.5mg compared to 0.5mg for the other two)
Spread protein across meals for better absorption
Loprinzi CL, Lacchetti C, Bleeker J, et al
Skipping meals or eating too quickly can also blunt semaglutide's effectiveness, because the medication works by slowing stomach emptying and promoting satiety over time
Slowed digestion, reduced appetite, dehydration, protein breakdown, and changes in the gut microbiome can all play a role