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Design and pharmacological characterization of cagrilintide (NNC0174-0833) Journal of Medicinal Chemistry, 2021

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As patients lose weight, the body undergoes compensatory changes including increased production of ghrelin (the "hunger hormone") and decreased leptin levels

It is possible that MAX2 is involved in KAR signaling without any interaction with HTL or that a third component is required to enhance the HTLMAX2 interaction, indicating a different pathway from SL signaling (Supplementary Fig