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The second induction study FIGARO UC 302 (NCT03259334) enrolled 279 participants using an identical design and demonstrated efficacy for both doses, with 25mg achieving clinical remission in 27.0% versus 12.5% placebo and 75mg achieving 29.5% versus 12.5% placebo, while both doses showed significant benefits across secondary endpoints including endoscopic response, clinical response, and mucosal healing, with inclusion criteria requiring patients aged 1866 years with moderate to severe disease and the studies showing good tolerability with most common adverse events being UC worsening, arthralgia, and nasopharyngitis

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To reduce discomfort, doctors suggest raising the dose over time

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It's important to note that weight regain is common if treatment is discontinued