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Conclusions and prospects In summary, GLP-1 receptor agonists (GLP-1RAs) have expanded from being merely metabolic regulation drugs to potential interventions for improving sarcopenia

Compared with GLP-1, dual agonists can avoid the degradation of dipeptidyl peptidase-4, thereby prolongating drug administration

Coronal sections (250 mm) were cut using the Leica VT1000S Vibratome and then incubated in oxygenated aCSF (3234 C) for at least 1 h before recordings

Individual results vary considerably, and understanding the factors that influence outcomes helps set realistic expectations and guide treatment optimization

Phase Phase 4 Weeks Week 13+ Daily dose 25 mg Notes Maintenance dose

10.1016/j.matbio.2018.02.020 153 WangC.LuoH.XuY.TaoL.ChangC.ShenX