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JACC Heart Fail 2(2):159165

These strains are classified as variants of concern (VOCs) [17], as the N501Y mutation present in variants from the UK (Alfa), South Africa (Beta), and Brazil (Gamma) that has shown an increase in ACE2 affinity causing enhanced infectivity and more severe COVID-19 [8, 18]

Some novel treatments like the use of finerenone or sodium-glucose cotransporter-2 inhibitors (SGLT2i) in combination with the classical renin-angiotensin-aldosterone system (RAAS) blockers are promising therapies (7)

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Atomoxetine, a novel treatment for attention-deficit-hyperactivity disorder