10.1007/s12013-014-0252-6 189 WangY
In SURMOUNT-1, the most common adverse events at the 15 mg dose included nausea (31%), diarrhea (23%), constipation (11%), and vomiting (12%)
Neither method alone establishes sterility, endotoxin control, biological activity, or clinical safety
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Chronic administration of high doses of oral levocarnitine in patients with severely compromised renal function or in ESRD patients on dialysis may result in accumulation of the potentially toxic metabolites, trimethylamine (TMA) and trimethylamine-N-oxide (TMAO), since these metabolites are normally excreted in the urine